Medical Toxicology and Applied Pharmacology

Hepatotoxicity and Drug-Induced Liver Injury

Hepatotoxicity occurs when toxins or drugs cause liver damage, which can lead to liver failure or chronic liver disease. Drug-induced liver injury (DILI) is a leading cause of liver transplantation. Research focuses on identifying early biomarkers, understanding metabolic pathways that contribute to toxicity, and developing safer pharmaceuticals. Improved preclinical screening and personalized medicine approaches help predict which patients are at higher risk for DILI, improving the safety of new drugs and treatments.